Organometallic Compounds
Medchemexpress LLC N-Boc-C1-PEG3-C3-NH2 | 194920-62-2 | 320.42 | 10 G
N-Boc-C1-PEG3-C3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. They exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
eMolecules N-(triethoxysilane-PEG36-PEG3-)-N-bis(PEG3-biotin) | | | 100mg
Broadpharm | N-(triethoxysilane-PEG36-PEG3-)-N-bis(PEG3-biotin) | 100mg | 550804629 | BP-24424 | 98.000 | | | 2884.640 | C129H251N9O54S2Si
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Medchemexpress LLC Methyl-PEG3-bromide 10g
Methyl-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]
Medchemexpress LLC 4,7,10-trioxa-3-siladodecan-12-ol, 2,2,3,3-tetramethyl- | 201037-95-8 | >=98.0% | 264.43 g/mol | C12H28O4Si | 1 G
TBDMS-PEG3-OH is a tert-butyldimethylsilyl-protected PEG3 linker with a terminal hydroxyl group. It is supplied as a colorless to light yellow liquid and is used as a short, flexible spacer in medicinal chemistry, linker synthesis, and drug-delivery research.
- tert-butyldimethylsilyl-protected terminal hydroxyl
- three ethylene glycol units (PEG3)
- molecular weight 264.43 g/mol
- chemical formula C12H28O4Si
- CAS number 201037-95-8
- purity >=98.0% (1H NMR)
- appearance colorless to light yellow liquid
- storage: pure form -20°C for 3 years; 4°C for 2 years
Medchemexpress LLC M-PEG3-OMs | 74654-05-0 | >98% | C8H18O6S | 250 MG
This product is m-PEG3-OMs, a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are compounds that leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting a ligand for an E3 ubiquitin ligase with a ligand for the target protein.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC N-Boc-PEG5-bromide | 1392499-32-9 | MFCD31536756 | 98.0% | 400.31 g/mol | C15H30BrNO6 | 1 G
N-Boc-PEG5-bromide is a Boc-protected polyethylene glycol (PEG5) bromide linker reagent used in organic synthesis for assembling antibody-drug conjugate (ADC) and proteolysis-targeting chimera (PROTAC) linkers. It supplies a protected amine and a reactive terminal bromide for nucleophilic substitution and coupling reactions, and is provided at high purity for research use.
- Provides a Boc-protected amine for temporary protection during synthesis.
- Offers a terminal bromide suitable for nucleophilic substitution and coupling reactions.
- PEG5 spacer increases solubility and flexibility in linker constructs.
- High purity appropriate for research and linker assembly.
- Stable under recommended storage conditions for extended shelf life.
eMolecules 1076199-21-7 | BocNH-PEG3-CH2CH2Br | Acrotein ChemBio Inc. | MFCD09840081 | 356.257 | C13H26BrNO5 | 97.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCBr | 1g | 499918270
BocNH-PEG3-CH2CH2Br | Acrotein ChemBio Inc. | 1076199-21-7 | MFCD09840081 | 356.257 | C13H26BrNO5 | 97.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCBr | 1g | 499918270
eMolecules 139115-92-7 | Boc-NH-PEG3 | Ambeed | MFCD07357496 | 249.307 | C11H23NO5 | 97.000 | CC(C)(C)OC(=O)NCCOCCOCCO | 5g | 552604531
Boc-NH-PEG3 | Ambeed | 139115-92-7 | MFCD07357496 | 249.307 | C11H23NO5 | 97.000 | CC(C)(C)OC(=O)NCCOCCOCCO | 5g | 552604531
Medchemexpress LLC Azide-PEG5-Boc | 1415800-41-7 | C17H33N3O7 | 500 MG
Azide-PEG5-Boc is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. PROTACs are designed to selectively degrade target proteins by utilizing the intracellular ubiquitin-proteasome system.
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an Azide group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC)
- Utilizes the intracellular ubiquitin-proteasome system to degrade target proteins
- For research use only
Medchemexpress LLC Ethanamine, 2-[2-[2-[(6-chlorohexyl)oxy]ethoxy]ethoxy]- | 1261350-60-0 | 95.0% | 267.79 | 25 MG
NH2-PEG3-C6-Cl is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker; one targets an E3 ubiquitin ligase, and the other targets a specific protein. This mechanism leverages the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Enables selective degradation of target proteins
Medchemexpress LLC Azido-PEG5-alcohol | 86770-68-5 | >97.0% | 263.29 g·mol⁻¹ | C10H21N3O5 | 5 G
Azido-PEG5-alcohol is an azide-terminated polyethylene glycol linker containing five ethylene glycol units and a terminal primary alcohol, used as a water-soluble reagent for bioconjugation and linker synthesis. It is commonly applied in click chemistry and in the construction of antibody-drug conjugates and PROTACs.
- Azide functionality enables CuAAC and SPAAC click reactions.
- Water-soluble PEG5 spacer improves solubility and flexibility.
- Terminal primary alcohol provides a synthetic handle for derivatization.
- Suitable for ADC linker synthesis and PROTAC construction.
- Supplied as a solid with reported purity >97.0%.
Medchemexpress LLC M-PEG3-Aminooxy | 248275-10-7 | 98.0% | C7H17NO4 | 250 MG
m-PEG3-Aminooxy is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are compounds that leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins. They consist of two distinct ligands linked together: one designed to bind to an E3 ubiquitin ligase and the other to the target protein.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC N-(Azido-PEG3)-N-(PEG2-amine)-PEG3-acid | 2183440-70-0 | 99.6% | C24H47N5O11 | 25 MG
N-(Azido-PEG3)-N-(PEG2-amine)-PEG3-acid is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. It acts as a versatile click chemistry reagent, facilitating selective degradation of target proteins via the intracellular ubiquitin-proteasome system.
- Contains an Azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules possessing Alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups
- Functions as a PROTAC linker
- Utilized in PROTAC synthesis
Medchemexpress LLC Azido-PEG3-C6-Cl | 1625717-44-3 | 95.30% | 293.79 | 25 MG
Azido-PEG3-C6-Cl is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. It functions as a click chemistry reagent, capable of undergoing both copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne groups and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent
- Contains an azide group
- Participates in CuAAc reactions with alkyne groups
- Undergoes SPAAC reactions with DBCO or BCN groups
Medchemexpress LLC M-PEG5-Br | 854601-80-2 | 98.0% | C11H23BrO5 | 5 G
m-PEG5-Br is a PEG-based PROTAC linker. It is for research use only and not for sale to patients. This linker can be used in the synthesis of PROTACs, which consist of two different ligands connected by a linker; one ligand is for an E3 ubiquitin ligase and the other is for the target protein. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Used in the synthesis of PROTACs
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only